Palmitoylethanolamide(PEA)isabio-identicalfattyacidamide thatIsnormallysynthesizedbyhealthytissueInthehumanbody inresponsetoinflammation.PEAismadebyvariousplantsand animalsandispresentthroughouttheanimalkingdom.PEAcan befoundinmanydifferenttissuesincludingglia,neurons,retina, white blood cells, mast cells and adipocytes.
Supplementing withPEAhasbeensclentlffcallyshowntonaturallyassistinthereduction ofinflammationandtohaveneuro-protectiveandpossiblypain controleffects.Thisnaturalanti-inflammatorysupportsthenervous system and abnormal immuneresponses.*
Palmitoylethanolamide (PEA) – backed by more than 300+ medical studies, has been shown to be or assist with:
Natural Pain Reliever
Neuroprotective at the cellular level
Pain and nervous system conditions
Muscle recovery and muscle pain
Immune system support
What are Glial and Mast Cells? Glial cells are various types of companion cells in the central and peripheral nervous system. Once thought to be nothing more than the glue that holds the brain together, these cells are now understood to have a much more complex role in the brain besides simply acting as a scaffold. Glial cells are responsible for nourishing neurons, facilitating nerve impulses, and exerting an inflammatory response on neurons.Dysregulation and over-activation of glial cells can have a detrimental effect on the nervous system[6,7,8].
Mast cells are a type of immune system cell that responds to chemical signals from tissue injury. When mast cells “degranulate,” they release a payload of inflammatory cytokines, NGF, histamines, and other molecules in the surrounding tissue. These chemicals attract white blood cells and activate their immune response against pathogens. Mast cells also activate nociceptors (pain receptors) with the chemicals they secrete.
How does it work? Palmitoylethanolamide is thought to act primarily on the Peroxisome Proliferator Activated Receptor Alpha (PPAR-α), a receptor in the cell nucleus. It also has affinity for the cannabinoid-like G-coupled receptors GPR55 and GPR119, although it has no affinity for the classical cannabinoid receptors CB1 and CB2. This is why it is sometimes referred to as a non-psychoactive “indirect endocannabinoid.”
It does not block pain signals the way opioids and other analgestics do. Instead it works upstream by supporting the healthy function of glial cells and mast cells.*
Pro GAD Enhancer, created by a leading neuro-immune specialist, was created to assist patients who have difficulty producing adequate amounts of GABA, an important brain neurotransmitter. GABA plays the principal role of reducing excitability throughout the nervous system, as well as, regulation of musde relaxation. Many patients possess a genetic mutation of GAD (Glutamic Acid Decarboxylase), the primary enzyme that creates GABA. A weakness in the GAD enzyme creates an increased amount of Glutamate, the primary excitatory neurotransmitter of the nervous system, and a relative deficiency of GABA. This imbalance creates an overly stimulated nervous system.
The 5 key ingredients are designed to assist with:
Vitamin D3 + K2 Cofactor Complex™ was designed to obtain the most benefit from Vitamin D. How well vitamin D delivers to the cell depends upon the amount of other cofactors in the body and if genetic weaknesses are present. Such genetic as the VDR Taq, may hinder vitamin D delivery unless vitamin K is present.
Vitamin D, Vitamin K, and the other cofactors, Boron and Zinc Picolinate, in this formula have been show to:
Supports Healthy Blood Circulation
Promotes Bone Health and Proper Calcium Storage
Supports Cardiovascular Health and Blood Sugar Balance
Boosts Immune Function
This formula includes the patented vitaMK7, a natural vitamin K2 (as MK7) which supports enhanced utilization of calcium in the bloodstream. Thi is a soy-free, vitamin D3 and vitamin K2 in the most bioavailable and bioactive forms.
* It is an all-trans natural menaquinone-7 with the highest bioavailability and longest half-life in the blood.*
VitaMK7® is shown in human clinical studies to increase osteocalcin (calcium-binding protein) levels, enhancing the body’s ability to utilize calcium in the bloodstream.
* An in-vitro study shows vitaMK7® inhibits the production of PGE-2, a prostaglandin that acts as a potent stimulator of bone loss.
* It is non-GMO and solvent free and processed under the strictest purity standards.
Our Price: $36.90
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnosis, treat, cure or prevent any disease.